This creamy Southwest Alfredo Penne Pasta brings a zesty twist to your dinner table! With penne pasta coated in a rich sauce, it’s packed with flavors from spices, cheese, and veggies.
Let’s face it, who can resist that creamy goodness? I sometimes add extra cheese because, why not? Serve it with garlic bread, and dinner is set! 🍽️
Key Ingredients & Substitutions
Penne Pasta: This pasta shape is perfect for holding onto the creamy sauce. If you don’t have penne, you can use rigatoni or even fusilli! Just make sure the pasta is sturdy enough to support the sauce.
Chicken: Boneless, skinless chicken breast works well here, but you could swap it for cooked shrimp or even diced tofu for a meatless option. Leftover chicken from a rotisserie works wonders too!
Spices: Chili powder, smoked paprika, and cumin give this dish its Southwest flair. If you’re out of some spices, taco seasoning can serve as a great substitute. It has a similar flavor profile, so don’t hesitate to use it!
Heavy Cream: For a lighter version, try using half-and-half or a non-dairy milk like cashew cream. It won’t be as thick, but it will still be creamy and delicious without all the calories.
Cilantro: Fresh cilantro adds a bright finish. If you’re not a fan, swap it out for parsley or just leave it off completely. Flavor is key here, and personal preference is important!
How Do I Get My Sauce to Be Creamy Without Curdling?
The key to a creamy Alfredo sauce is to control the heat. Start by heating the heavy cream gently. Here’s how to do it:
- After sautéing the garlic and optional peppers, reduce the heat to medium before adding the cream. This prevents it from boiling.
- Stir the cream frequently as you add the cheeses. This helps meld them into a luscious sauce without separating.
- If you see the cream starting to bubble, lower the temperature to avoid curdling. Remove it from the heat immediately if needed.
This careful heating makes sure your sauce stays silky and smooth!

Southwest Alfredo Penne Pasta
Ingredients You’ll Need:
For the Pasta:
- 12 oz penne pasta
- 2 tbsp olive oil
For the Chicken:
- 1 lb boneless, skinless chicken breast, cut into bite-sized pieces
- 1 tsp chili powder
- 1 tsp smoked paprika
- 1/2 tsp ground cumin
- 1/2 tsp garlic powder
- Salt and pepper to taste
For the Sauce:
- 2 cloves garlic, minced
- 1 cup heavy cream
- 1 cup shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
For the Toppings:
- 1/2 cup diced tomatoes (fresh or canned)
- 1/4 cup chopped fresh cilantro
- 1/2 cup diced green bell pepper or poblano pepper (optional, for more Southwest flavor)
How Much Time Will You Need?
This delicious dish will take about 30 minutes total. You’ll spend about 10 minutes cooking the pasta and 20 minutes preparing the creamy sauce with chicken and spices. Quick and satisfying—perfect for any weeknight dinner!
Step-by-Step Instructions:
1. Cook the Pasta:
Start by boiling a pot of salted water. Add the penne pasta and cook according to the package instructions until it is al dente. Once done, drain the pasta and set it aside for later.
2. Sauté the Chicken:
In a large skillet, heat the olive oil over medium-high heat. Toss in the bite-sized chicken pieces. Season them with chili powder, smoked paprika, ground cumin, garlic powder, salt, and pepper. Cook the chicken for about 6-8 minutes until it’s nicely browned and cooked through. Once done, remove the chicken from the skillet and set it aside.
3. Make the Alfredo Sauce:
In the same skillet, add the minced garlic and the optional diced bell or poblano pepper. Sauté for about 1-2 minutes until they are fragrant and tender. Then, reduce the heat to medium and pour in the heavy cream. Let it simmer gently for a minute.
4. Combine the Cheeses:
Add the shredded mozzarella and grated Parmesan cheeses to the simmering cream. Stir them in until they melt completely into a creamy sauce. Make sure to stir frequently to keep the sauce smooth.
5. Bring It All Together:
Add the cooked chicken, diced tomatoes, and drained pasta into the skillet. Toss everything together until the pasta and chicken are thoroughly coated with the creamy Southwest Alfredo sauce.
6. Final Touches:
Remove the skillet from heat and garnish your dish with chopped fresh cilantro. If you like, sprinkle a little extra shredded cheese on top for that cheesy goodness.
7. Serve and Enjoy!
Serve your Southwest Alfredo Penne Pasta immediately. It pairs wonderfully with garlic bread or a fresh green salad. Enjoy this creamy, flavorful bowl of pasta that’s bursting with delicious Southwest flavors!
Can I Use Whole Wheat Pasta Instead of Regular Penne?
Absolutely! Whole wheat pasta is a great substitute and adds more nutrients and fiber to your meal. Just be sure to adjust the cooking time a bit, as whole wheat pasta may require an extra minute or two to cook to al dente.
Can I Make This Recipe Vegetarian?
Yes, you can easily make this dish vegetarian by omitting the chicken and using extra vegetables instead. Consider adding bell peppers, zucchini, or mushrooms for added flavor and texture. You could also substitute the chicken with some canned black beans or chickpeas for protein.
How Do I Store Leftovers?
Store any leftovers in an airtight container in the refrigerator for up to 3 days. When you’re ready to enjoy them, simply reheat in the microwave or on the stovetop over low heat, adding a splash of cream or a little milk to help revive the sauce.
What Toppings Can I Add for Extra Flavor?
You can enhance this dish with various toppings! Try adding sliced jalapeños for some heat, avocado for creaminess, or a squeeze of lime juice to brighten the flavors. Crushed tortilla chips can also provide a nice crunch on top!



